Motif ID: STAT5{A,B}.p2

Z-value: 1.444


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Bchr17_-_40428391-0.472.3e-01Click!
STAT5Achr17_+_40439564-0.423.1e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_44860798 1.701 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr5_+_178450775 1.507 NM_001136116
ZNF879
zinc finger protein 879
chr19_+_35168558 1.452 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr19_+_44617510 1.313 NM_013362
ZNF225
zinc finger protein 225
chr19_-_44405934 1.105 LOC100505715
uncharacterized LOC100505715
chr19_-_44809126 1.091 NM_004234
ZNF235
zinc finger protein 235
chr19_+_44764032 1.077 NM_001207005
NM_181756
ZNF233

zinc finger protein 233

chr5_-_111093251 1.067 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr9_-_115774471 0.943 NM_001101338
ZNF883
zinc finger protein 883
chr11_+_65268313 0.942 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr19_+_44529493 0.899 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_-_37958338 0.871 NM_152484
ZNF569
zinc finger protein 569
chr19_+_35225095 0.853 ZNF181
zinc finger protein 181
chr19_+_44669214 0.845 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr6_-_27440459 0.802 NM_007149
ZNF184
zinc finger protein 184
chr19_+_44556163 0.784 NM_013361
ZNF223
zinc finger protein 223
chr19_+_44488331 0.770 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_-_58090071 0.720 NM_017879
ZNF416
zinc finger protein 416
chr20_-_18477811 0.713 NM_006606
RBBP9
retinoblastoma binding protein 9
chr11_-_82996898 0.712 CCDC90B
coiled-coil domain containing 90B
chr19_-_58090254 0.712 ZNF416
zinc finger protein 416
chr1_+_153631193 0.685 SNAPIN
SNAP-associated protein
chr19_-_44439410 0.655 NM_003425
ZNF45
zinc finger protein 45
chr11_-_82997376 0.651 NM_021825
CCDC90B
coiled-coil domain containing 90B
chr1_+_153631144 0.650 NM_012437
SNAPIN
SNAP-associated protein
chr19_+_44716683 0.648 NM_182490
ZNF227
zinc finger protein 227
chr19_+_37709068 0.624 ZNF383
zinc finger protein 383
chr19_-_36980336 0.620 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr7_+_99102272 0.619 NM_145102
ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr19_+_44507076 0.609 NM_006300
ZNF230
zinc finger protein 230
chr19_-_40596781 0.597 NM_001010880
NM_001142577
NM_001142578
NM_001142579
ZNF780A



zinc finger protein 780A



chr19_-_36980758 0.591 ZNF566
zinc finger protein 566
chr19_+_58816714 0.580 ERVK3-1
endogenous retrovirus group K3, member 1
chr9_+_130186652 0.578 NM_007135
ZNF79
zinc finger protein 79
chr5_-_92916924 0.576 FLJ42709
uncharacterized LOC441094
chr19_+_44645728 0.540 ZNF234
zinc finger protein 234
chr19_+_44576266 0.534 NM_001037813
ZNF284
zinc finger protein 284
chr5_+_178286913 0.526 NM_058230
ZNF354B
zinc finger protein 354B
chr9_+_130186714 0.525 ZNF79
zinc finger protein 79
chr19_+_35225479 0.521 NM_001029997
NM_001145665
ZNF181

zinc finger protein 181

chr19_+_58816757 0.519 ERVK3-1
endogenous retrovirus group K3, member 1
chr9_+_104161118 0.514 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr12_+_133657478 0.509 ZNF140
zinc finger protein 140
chr7_-_93633527 0.493 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr12_+_133657439 0.490 ZNF140
zinc finger protein 140
chr19_-_58951588 0.476 NM_003433
ZNF132
zinc finger protein 132
chrX_-_154250769 0.475 NM_000132
F8
coagulation factor VIII, procoagulant component
chr11_+_73357222 0.461 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_+_58258189 0.448 ZNF776
zinc finger protein 776
chr19_-_57183122 0.446 NM_001005850
ZNF835
zinc finger protein 835
chr7_+_99102572 0.445 NM_014569
ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chrX_+_106045880 0.441 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr11_-_134123138 0.424 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr22_-_38902281 0.422 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr12_+_133656984 0.421 NM_003440
ZNF140
zinc finger protein 140
chr19_+_58258160 0.397 NM_173632
ZNF776
zinc finger protein 776
chr1_-_109618568 0.395 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr19_+_39882018 0.392 MED29
mediator complex subunit 29
chr7_+_142829169 0.390 NM_002652
PIP
prolactin-induced protein
chr19_-_44617271 0.384 LOC100379224
uncharacterized LOC100379224
chr19_+_17530841 0.383 FAM125A
family with sequence similarity 125, member A
chr2_+_95831176 0.380 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr11_-_55703875 0.379 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr19_-_38085646 0.375 NM_016536
ZNF571
zinc finger protein 571
chr16_-_67260720 0.374 NM_012163
LRRC29
leucine rich repeat containing 29
chr12_-_10324675 0.368 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr16_+_53468373 0.361 RBL2
retinoblastoma-like 2 (p130)
chr16_+_2802656 0.355 SRRM2
serine/arginine repetitive matrix 2
chr3_+_58484091 0.351 NM_153331
KCTD6
potassium channel tetramerisation domain containing 6
chr20_+_12989616 0.348 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr19_+_44598479 0.346 NM_013398
ZNF224
zinc finger protein 224
chr19_+_58331067 0.346 LOC100293516
zinc finger protein
chr22_-_38902344 0.346 NM_001098504
NM_006386
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr22_-_38902300 0.344 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_+_39881950 0.342 NM_017592
MED29
mediator complex subunit 29
chr19_+_37341259 0.340 NM_003419
ZNF345
zinc finger protein 345
chr13_-_99404883 0.337 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr3_+_130745693 0.332 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr19_-_37406918 0.326 NM_001171979
ZNF829
zinc finger protein 829
chr17_+_5323471 0.321 RPAIN
RPA interacting protein
chr6_-_83903632 0.321 NM_001199917
PGM3
phosphoglucomutase 3
chr14_+_24630421 0.317 NM_006084
IRF9
interferon regulatory factor 9
chr19_+_9251052 0.305 NM_001190791
NM_020933
ZNF317

zinc finger protein 317

chr16_+_53468406 0.305 RBL2
retinoblastoma-like 2 (p130)
chr16_+_15596122 0.297 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr19_-_50528683 0.296 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr7_+_99102601 0.285 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr4_+_156824846 0.278 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr8_+_110346549 0.278 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr19_-_37019169 0.278 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr10_-_38265452 0.273 NM_145011
ZNF25
zinc finger protein 25
chr19_+_40502942 0.270 NM_178544
ZNF546
zinc finger protein 546
chr11_-_58611979 0.268 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr2_-_63815761 0.266 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr15_-_74753431 0.265 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr3_-_183735617 0.261 NM_001023587
NM_005688
ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr5_-_177423242 0.256 NM_006261
PROP1
PROP paired-like homeobox 1
chr11_+_134123406 0.255 NM_014384
ACAD8
acyl-CoA dehydrogenase family, member 8
chr19_+_58361219 0.252 ZNF587
zinc finger protein 587
chr7_+_128502926 0.251 ATP6V1F
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
chr14_-_20881577 0.250 NM_007110
TEP1
telomerase-associated protein 1
chr1_-_155112720 0.249 NM_018973
NM_153741
DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr19_-_44952630 0.249 NM_014518
ZNF229
zinc finger protein 229
chr17_-_26662439 0.246 NM_174887
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr19_-_44905754 0.243 NM_152354
ZNF285
ZFP112
zinc finger protein 285
zinc finger protein 112 homolog (mouse)
chr19_-_56904869 0.240 NM_144690
ZNF582
zinc finger protein 582
chr2_-_27886443 0.236 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr19_+_58144510 0.236 NM_006385
NM_198855
ZNF211

zinc finger protein 211

chr6_+_139094656 0.234 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr5_+_140753480 0.234 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr12_+_120972103 0.232 NM_014868
RNF10
ring finger protein 10
chr5_-_95158365 0.230 GLRX
glutaredoxin (thioltransferase)
chr15_+_91643429 0.230 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr19_+_37407230 0.229 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr12_-_133532847 0.227 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr5_+_85913755 0.226 COX7C
cytochrome c oxidase subunit VIIc
chr5_-_145562068 0.226 LARS
leucyl-tRNA synthetase
chr3_-_157213138 0.223 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr15_-_74753490 0.222 NM_032907
NM_201265
UBL7

ubiquitin-like 7 (bone marrow stromal cell-derived)

chr7_-_150754934 0.220 CDK5
cyclin-dependent kinase 5
chr7_+_142985307 0.219 NM_032982
NM_032983
CASP2

caspase 2, apoptosis-related cysteine peptidase

chr16_+_53738044 0.217 FTO
fat mass and obesity associated
chr16_+_53468390 0.213 RBL2
retinoblastoma-like 2 (p130)
chr12_+_21284127 0.212 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr3_-_183543295 0.211 NM_024871
MAP6D1
MAP6 domain containing 1
chr2_-_63815581 0.208 WDPCP
WD repeat containing planar cell polarity effector
chr16_+_53468362 0.207 RBL2
retinoblastoma-like 2 (p130)
chr7_+_128502856 0.206 NM_001198909
NM_004231
ATP6V1F

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

chr19_-_45004482 0.203 NM_013256
ZNF180
zinc finger protein 180
chr19_-_58514136 0.202 ZNF606
zinc finger protein 606
chr19_+_58281049 0.202 ZNF586
zinc finger protein 586
chr1_-_31230673 0.200 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr16_+_53468344 0.199 NM_005611
RBL2
retinoblastoma-like 2 (p130)
chr5_+_140474198 0.198 NM_018936
PCDHB2
protocadherin beta 2
chr18_+_43684297 0.196 NM_138443
HAUS1
HAUS augmin-like complex, subunit 1
chr5_-_145562214 0.193 LARS
leucyl-tRNA synthetase
chr16_-_279338 0.193 NM_018032
NM_201412
LUC7L

LUC7-like (S. cerevisiae)

chr19_-_35264091 0.192 NM_001007248
ZNF599
zinc finger protein 599
chr10_+_93558182 0.190 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr11_+_86013252 0.190 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr16_+_2802605 0.190 SRRM2
serine/arginine repetitive matrix 2
chr2_+_172290796 0.189 DCAF17
DDB1 and CUL4 associated factor 17
chr2_-_241500459 0.188 ANKMY1
ankyrin repeat and MYND domain containing 1
chr1_+_54519259 0.187 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr17_+_15603046 0.184 ZNF286A
zinc finger protein 286A
chr14_-_77923888 0.182 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
C14orf133




chromosome 14 open reading frame 133




chr10_-_131909061 0.181 LOC387723
uncharacterized LOC387723
chr4_+_86396251 0.177 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr14_-_77889231 0.172 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr16_+_4674819 0.172 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr19_-_50528627 0.169 VRK3
vaccinia related kinase 3
chr11_+_2920910 0.167 NM_183233
SLC22A18
solute carrier family 22, member 18
chr20_+_39657612 0.165 TOP1
topoisomerase (DNA) I
chr12_-_46384346 0.163 SCAF11
SR-related CTD-associated factor 11
chr1_-_19217384 0.162 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr5_-_137514299 0.160 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr19_+_17416476 0.158 NM_023937
MRPL34
mitochondrial ribosomal protein L34
chr17_-_33700619 0.157 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr2_+_74740585 0.156 TLX2
T-cell leukemia homeobox 2
chr8_-_146012653 0.155 NM_030580
ZNF34
zinc finger protein 34
chr19_+_58280996 0.153 NM_001077426
NM_001204814
NM_017652
ZNF586


zinc finger protein 586


chr10_+_93558068 0.152 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr16_-_70472920 0.152 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr16_+_67204404 0.150 NM_001185058
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr12_+_80603232 0.149 NM_173591
OTOGL
otogelin-like
chr15_+_75315931 0.147 PPCDC
phosphopantothenoylcysteine decarboxylase
chrY_+_2709596 0.146 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr5_+_32585604 0.146 NM_006713
SUB1
SUB1 homolog (S. cerevisiae)
chr1_+_53392957 0.146 SCP2
sterol carrier protein 2
chr20_-_25677173 0.145 NM_015655
ZNF337
zinc finger protein 337
chr10_-_7453412 0.145 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr15_-_83735892 0.145 BTBD1
BTB (POZ) domain containing 1
chr10_+_93558139 0.144 NM_025235
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr22_+_22020272 0.144 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr1_+_162466963 0.142 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr1_+_162039469 0.141 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr11_+_67374322 0.138 NM_001166102
NM_007103
NDUFV1

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

chr5_+_137514416 0.137 NM_005733
KIF20A
kinesin family member 20A
chr11_+_71640088 0.135 RNF121
ring finger protein 121
chr11_+_114167168 0.134 NNMT
nicotinamide N-methyltransferase
chr6_-_111136616 0.133 CDK19
cyclin-dependent kinase 19
chr15_-_83736105 0.133 NM_001011885
NM_025238
BTBD1

BTB (POZ) domain containing 1

chr1_+_53392900 0.132 NM_001007098
NM_001193599
NM_001193600
NM_001193617
NM_002979
SCP2




sterol carrier protein 2




chr5_+_137514753 0.132 KIF20A
kinesin family member 20A
chr1_+_149871154 0.132 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chrY_+_2709630 0.129 RPS4Y1
ribosomal protein S4, Y-linked 1
chr15_+_75315926 0.129 NM_021823
PPCDC
phosphopantothenoylcysteine decarboxylase
chr19_+_17378264 0.127 BABAM1
BRISC and BRCA1 A complex member 1
chr18_-_43684198 0.126 NM_001001937
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chrX_-_48931645 0.125 NM_007213
PRAF2
PRA1 domain family, member 2
chr6_-_159240398 0.122 EZR
ezrin
chr19_+_40477032 0.121 NM_006503
NM_153001
PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr3_+_180319898 0.121 NM_001042601
NM_133462
TTC14

tetratricopeptide repeat domain 14

chr19_+_44455379 0.119 NM_013359
ZNF221
zinc finger protein 221
chr19_+_17378148 0.119 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr5_+_85913762 0.119 NM_001867
COX7C
cytochrome c oxidase subunit VIIc
chr4_+_130017281 0.116 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr16_+_4674829 0.116 MGRN1
mahogunin, ring finger 1
chr20_+_39657461 0.116 NM_003286
TOP1
topoisomerase (DNA) I
chr7_-_150754979 0.115 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.38 4.15e-11 GO:0006355 regulation of transcription, DNA-dependent
2.28 6.31e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.25 9.97e-11 GO:0010556 regulation of macromolecule biosynthetic process
2.16 2.18e-10 GO:0009889 regulation of biosynthetic process
2.16 3.12e-10 GO:0031326 regulation of cellular biosynthetic process
2.29 3.32e-10 GO:0051252 regulation of RNA metabolic process
2.18 5.41e-10 GO:0010468 regulation of gene expression
2.07 4.65e-09 GO:0051171 regulation of nitrogen compound metabolic process
2.07 1.58e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.89 4.12e-08 GO:0060255 regulation of macromolecule metabolic process
1.81 3.53e-07 GO:0031323 regulation of cellular metabolic process
1.81 3.66e-07 GO:0080090 regulation of primary metabolic process
1.74 8.03e-07 GO:0019222 regulation of metabolic process
1.28 3.39e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 1.43e-09 GO:0043231 intracellular membrane-bounded organelle
1.40 1.62e-09 GO:0043227 membrane-bounded organelle
1.36 1.68e-09 GO:0043229 intracellular organelle
1.35 2.10e-09 GO:0043226 organelle
1.61 3.10e-09 GO:0005634 nucleus
1.24 1.70e-06 GO:0044424 intracellular part
1.23 4.26e-06 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.58 9.14e-15 GO:0008270 zinc ion binding
2.37 2.45e-13 GO:0046914 transition metal ion binding
2.27 1.75e-11 GO:0003677 DNA binding
1.91 1.39e-09 GO:0003676 nucleic acid binding
1.69 6.51e-07 GO:0046872 metal ion binding
1.67 1.24e-06 GO:0043169 cation binding
1.67 1.43e-06 GO:0043167 ion binding